We are developing new diffusion magnetic resonance imaging (dMRI) methods that give information about tissue microstructure in the living human brain at an unprecedented level of detail and precision. The new methods are designed to meet the currently increasing clinical demands for non-invasive techniques to assess cellular changes caused by pathological conditions, such as multiple sclerosis, cancer, Alzheimer’s disease, and traumatic brain injury. The multi-disciplinary research program, involving PIs from applied mathematics, information theory, medical physics, radiology, and physical chemistry, is proceeding according to the following plan:
- Development of mathematical tools for microgeometry reconstruction from new dMRI pulse sequences.
- Method validation using computer simulations and experiments on materials with known structure.
- Development of software for experiment set-up, data processing, and visualization.
- Measurements on healthy volunteers and selected patients.
- Dissemination of the methods by researcher exchange with MRI sites world-wide.
Patent protection of the key features of the new technology allow for future commercialization and strengthening of the Swedish medical technology industry.